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doi: 10.1002/mnfr.200400098 158 MacCarroneMLorenzonTGuerrieriPAgrAF

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Two things can be simultaneously true: a vial may test as 99% chemically pure with the correct molecule and concentration, and still be a biological hazard by other parameters entirely

Vagal afferents detect luminal and mucosal chemical cues, respond to gut hormones and neurotransmitters, and relay information on nutrient availability and microbial metabolites to the central nervous system [26]